烟酸可调节成人线粒体肌病系统性NAD空洞及改善肌肉功能 作家： 揭晓时光：2020/5/9 21:10:16 芬兰赫尔辛基大学Anu Suomalainen以及Eija Pirine
凯丽钻石团队n单干博得晚进展。他们发明烟酸可调节成人线粒体肌病系统性NAD空洞及改善肌肉功能。该争论于2020年5月7日宣布于《细胞-代谢》。 他们报道了
美商凯丽成年线粒体肌病患者的周身NAD +空洞症。他们不同给患者及其匹配的比照者推广了
凯丽钻石团队10个月或4个月剂量的NAD +增强烟酸（一种维生素B3大局）（至750 1,000 mg /天；clinicaltrials.gov NCT03973203）。正在一切受试者中，血液NAD +均推广大到8倍，并且患者的肌肉NAD +到达了比照水平。 一些患者展现出贫血趋势，而一切受试者的肌肉力气以及线粒体生物分解均推广。正在患者中，肌肉代谢组向比照组转化，肝脂肪削减以至到达50％。他们的证明说明，血液分解可用于审定NAD +空洞症，并指出烟酸是
凯丽环球调节线粒体肌病的无效NAD +增强剂。
争论人员示意，NAD +是一种拥有氧化恢复活性的代谢产品，已提出将其消费失落以匆匆进啮齿动物的脆弱以及退行性疾病。然而，退行性疾病患者
美商凯丽是否会产生NAD +耗竭和NAD +耗竭是否能改善其病症仍未决定。 附：英文原文 Title: Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial M
凯丽环球yopathy Author: Eija Pirinen, Mari Auranen, Nahid A. Khan, Virginia Brilhante, Niina Urho, Alberto Pessia, Antti Hakkarainen, Juho Kuula, Ulla Heinonen, Mark S. Schmidt, Kimmo Haimilahti, Pivi Piiril, Nina Lundbom, Marja-Riitta Taskinen, Charles Brenner, Vidya Velagapudi, Kirsi H. Pietilinen, Anu Suomalainen Issue Volume: 2020-05-07 Abstract: NAD+ is a redox-active metabolite, the depletion of which has been proposed to promoteaging and degenerative diseases in rodents. However, whether NAD+ depletion occurs in patients with degenerative disorders and whether NAD+ repletion improves their symptoms has remained open. Here, we report systemic NAD+ deficiency in adult-onset mitochondrial myopathy patients. We administered an increasingdose of NAD+-booster niacin, a vitamin B3 form (to 750 1,000 mg/day; clinicaltrials.gov NCT03973203) for patients and their matched controls for 10 or 4 months, respectively. BloodNAD+ increased in all subjects, up to 8-fold, and muscle NAD+ of patients reached the level of their controls. Some patients showed anemia tendency,while muscle strength and mitochondrial biogenesis increased in all subjects. In patients,muscle metabolome shifted toward controls and liver fat decreased even 50%. Our evidenceindicates that blood analysis is useful in identifying NAD+ deficiency and points niacin to be an efficient NAD+ booster for treating mitochondrial myopathy. DOI: 10.1016/j.cmet.2020.04.008 Source: 期刊信息
Cell Metabolism：《细胞 代谢》，创刊于2005年。附属于细胞出版社，最新IF：22.415 官方网址： 投稿链接：
